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Topiramate was released for commercial use in In addition, Topiramate has been used to treat partial-onset or primary generalized tonic-clonic seizures, Lennox-Gastaut syndrome, and as a prophylactic treatment of migraine headaches. The United States Food and Drug Administration approved the combination of these two drugs in to treat obesity. Topiramate was discovered in but was not released for commercial use until Topiramate on its own has been used to treat partial-onset or primary generalized tonic-clonic seizures, Lennox-Gastaut syndrome, and as a prophylactic treatment of migraine headaches. It is a central nervous system stimulant. Topiramate is an anticonvulsant lowering the seizure threshold stabilizing membrane by acting on high-voltage-activated calcium channels and voltage-gated sodium channels and its augmenting effect on GABA-A receptors. Topiramate is also a weak carbonic anhydrase inhibitor, and it also antagonizes glutamate receptors. Topiramate augments appetite suppression and satiety enhancement based on the combination of the mechanisms above. The plasma protein binding decreases as blood topiramate increases.

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